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8
Sliding filament hypothesis: What is the molecular basis of contraction? F-actin, myosin, troponin-tropomyosin, Ca-Ions, ATP. Which of these components represent the trigger for contraction? What happens if ATP is lacking? What’s the role of troponin-tropomyosin?
•The thick and thin filaments comprise the contractile machinery of the muscle.
•In a contracting muscle adjacent thick and thin filaments slide past each other, propelled by cyclical interactions between the myosin heads of the thick filaments and binding sites on the actin of the adjacent thin filaments.
•This mechanism is triggered by Ca2+ influx and uses ATP as energy source.
•The troponin-tropomyosin complex and F actin form the thin filament.
•In a contracting muscle adjacent thick and thin filaments slide past each other, propelled by cyclical interactions between the myosin heads of the thick filaments and binding sites on the actin of the adjacent thin filaments.
•This mechanism is triggered by Ca2+ influx and uses ATP as energy source.
•The troponin-tropomyosin complex and F actin form the thin filament.
