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10
What are the Type II hypersensitivity AI diseases? What's the pathogenesis?
AI Hemolytic Anemia
IgG and IgM against RH antibodies on RBCs.
=> Complement activation & Enhanced phagocytosis
3 methods of destruction:
1) FcR+ on macrophages => Destruction
2) Binds comlement=> recruits Macrophages=>Destruction
3) Binds complement=> Complement mediated Lysis
Goodpasture's Sydnrome
IgG targets Type IV Collagen.
Antibody deposits => Kidney problems.
IgG and IgM against RH antibodies on RBCs.
=> Complement activation & Enhanced phagocytosis
3 methods of destruction:
1) FcR+ on macrophages => Destruction
2) Binds comlement=> recruits Macrophages=>Destruction
3) Binds complement=> Complement mediated Lysis
Goodpasture's Sydnrome
IgG targets Type IV Collagen.
Antibody deposits => Kidney problems.
