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All main topics / Pharmacology / DM drugs

Diabetes (56 Cards)

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1
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List the insulin preps and their onset/duration
Crystalline insulin - rapid onset, short duration

Split mix - mix of crystalline and intermediate

Intermediate Insulin
Tags: diabetes, drug classes, endo, pharmacology, Type I diabetes
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2
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List the meglitinides
repaglinide
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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3
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Mechanism of action of meglitinides
inhibit the ATP/K+ channel
Tags: classes, diabetes, endo, mechanisms, pharmacology, type 2 diabetes
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4
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List the incretin mimetics
exenatide
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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5
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Mechanism of action of incretin mimetics
GLP1 agonist
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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6
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Side effects of incretin mimetics
TERATOGEN

also, it's from Gila Monster saliva.
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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7
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List the Gliptins
sitagliptin
vildagliptin
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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8
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List the DPP4 inhibitors
sitagliptin
vildagliptin
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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9
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Mechanism of action of the Gliptins
inhibit DPP4, blocking GLP-1 and GIP metabolism
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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10
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Mechanism of action of DPP4 inhibitors
block the metabolism of GLP-1 and GIP
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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11
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Functions of oral hypoglycemics
increase insulin
decrease glucagon
induce hypoglycemia
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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12
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List the Oral Anti-Hyperglycemics
TZDs/PPAR-gamma agonists
biguanides
alpha-glucosidase inhibitors
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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13
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List the TZDs
rosiglitazone
pioglitazone
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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14
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Mechanism of TZDs
PPAR-gamma agonists, causing increased membrane GLUT4, decreased inflammatory proteins
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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15
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List the PPAR-gamma agonists
rosiglitazone
pioglitazone
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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16
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Mechanism of PPAR-gamma agonists
increase membrane GLUT4
decrease inflammatory proteins
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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17
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Side effects of TZDs
takes 6-12 weeks to be effective

HEPATOTOXIC

CAUSES MI
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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18
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Side effects of PPAR-gamma agonists
takes 6-12 weeks to be effective

HEPATOTOXIC

CAUSES MI
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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19
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List the biguanides
metformin
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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20
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Mechanism of biguanides
blocks GNG
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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21
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Side effects of Biguanides
weight loss
improvement of lipid profile
LACTIC ACID ACIDOSIS
RENAL FAILURE WITH IODINATED CONTRAST
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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22
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List the alpha-glucosidase inhibitors
acarbose
miglitol
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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23
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Mechanism of alpha-glucosidase inhibitors
stops intestinal absorption of carbohydrates
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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24
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The only drug that can be used for insulin-dependent or insulin-independent diabetes
pralimitide: amylin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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25
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Lispro is a...
short-acting insulin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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26
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Aspart is a...
short-acting insulin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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27
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Glargine is a...
long-acting insulin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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28
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Glulisine is a...
short-acting insulin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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29
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Detemir is a...
intermediate-acting insulin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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30
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Acetohexamide is a...
first generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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31
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Tolbutamide is a...
first generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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32
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Tolazamide is a...
first generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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33
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Acetohexamide is a...
first generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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34
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Chlorpropamide is a...
first generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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35
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Glyburide is a...
second generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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36
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Glipizide is a...
second generation sulfonylurea oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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37
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Repaglinide is a...
meglitinide oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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38
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Exenatide is a...
incretin mimetic oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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39
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Sitagliptin is a...
DPP4 inhibitor/gliptin oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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40
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Vildagliptin is a...
DPP4 inhibitor/gliptin oral hypoglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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41
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Rosiglitazone is a...
TZD/PPAR-gamma agonist oral anti-hyperglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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42
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Pioglitazone is a...
TZD/PPAR-gamma agonist oral anti-hyperglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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43
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Metformin is a...
biguanide oral anti-hyperglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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44
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Acarbose is a...
alpha-glucosidase inhibitor oral anti-hyperlycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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45
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Miglitol is a...
alpha-glucosidase inhibitor oral anti-hyperglycemic
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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46
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Pramlinitide is a...
amylin analog injectable Type 1 and Type 2 diabetic drug
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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47
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List the short-acting Insulin Analogs
lispro
aspart
glulisine
Tags: diabetes, drugs, endo, pharmacology, Type I diabetes
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48
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List the long-acting Insulin Analogs
glargine
Tags: diabetes, drugs, endo, pharmacology, Type I diabetes
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49
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List the intermediate-acting Insulin Analogs
detemir - binds to albumin
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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50
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List the Oral Hypoglycemics and their mechanisms
Sulfonylureas - inhibit ATP/K+ channels

Meglitinides - inhibit ATP/K+ channels

Incretin Mimetics (exenatide) - GLP1 agonists

Gliptins - inhibit DPP4 and block GLP1 and GIP metabolism

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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51
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Tell me everything about first generation Sulfonylureas (names, mechanism, side effects)
tolbutamide, tolazamide, acetohexamide, chlorpropamide

inhibit ATP/K+ channels

SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS
WEIGHT GAIN

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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52
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List the second generation Sulfonylureas
glyburide, glipizide
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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53
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List the first generation Sulfonylureas
tolbutamide
tolazamide
acetohexamide
chlorpropamide
Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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54
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Mechanism of first generation Sulfonylureas
inhibit ATP/K+ channels
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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55
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Mechanism of second generation Sulfonylureas
inhibit ATP/K+ channels AND increase insulin receptors on tissues
Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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56
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Side effects of sulfonylureas
First generation: SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS, weight gain

Second generation: weight gain only
Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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Flashcard set info:
Author: larsonsc
Main topic: Pharmacology
Topic: DM drugs
School / Univ.: MSUCOM
Published: 10.03.2010
 
Card tags:
All cards (56)
classes (1)
diabetes (56)
drug classes (19)
drugs (36)
endo (56)
mechanisms (11)
pharmacology (56)
type 1 diabetes (8)
type 2 diabetes (47)
Type I diabetes (3)
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